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Bedfordshire and Luton Joint Formulary
Bedfordshire Hospitals NHS Foundation Trust
Bedfordshire, Luton and Milton Keynes ICB
Formulary Chapter: 8 - Malignant disease and immunosuppression 
Notes:

Any drug not listed on the Formulary should be considered Non-Formulary - Not recommended for prescribing
08.01.02 Anthracyclines and other cytotoxic antibiotics

Bleomycin

RED
Formulary
unlicensedunlicensed 7000Units in Sodium Chloride 0.9% Injection
unlicensedunlicensed 14000Units, 16000Units, 17000Units, 18000Units, 19000Units, 20000Units, 21000Units & 22000Units in 0.9% Sodium Chloride Infusion (100mL)

Restricted - must seek authorisation from a consultant before prescribing
BNF BNFc SPC

Cytarabine - Daunorubicin (liposomal) (Vyxeos®)
(Infusion)

RED
Restricted Drug Restricted

FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage. OR may be funded through the Cancer Drug Fund. Approved in accordance with the NICE TA below.

BNF BNFc SPC
NICE TA552: Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemia

Daunorubicin

RED
Restricted Drug Restricted
20mg powder for injection
BNF BNFc SPC

Doxorubicin Hydrochloride

RED
Restricted Drug Restricted
10mg/5mL, 20mg/10mL, 35mg/17.5mL & 60mg/30mL Syringe
unlicensedunlicensed 40mg in 5% Glucose Infusion (250mL)



BNF BNFc SPC

Epirubicin hydrochloride

RED
Restricted Drug Restricted
unlicensedunlicensed 10mg/5mL, 20mg/10mL, 30mg/15mL & 60mg/30mL Syringe
50mg/25mL Injection Solution

BNF BNFc SPC

Liposomal Doxorubicin Hydrochloride (Caelyx®)

RED
Restricted Drug Restricted
FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
Restricted to be used in line with NICE TA389.

2 mg/ml concentrate for solution for infusion in a pegylated liposomal formulation.
BNF BNFc SPC
NICE TA389: Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cance

Mitomycin

RED
Restricted Drug Restricted

unlicensedunlicensed 8mg, 9mg, 10mg, 11mg, 12mg & 14mg in Sodium Chloride 0.9% Pre-filled Syringe
2mg, 20mg & 40mg Injection
1.2mg/3mL Water for injection Pre-filled Syringe

BNF BNFc SPC

Mitoxantrone (Mitozantrone)

RED
Restricted Drug Restricted
25mg/12.5mL Injection
unlicensedunlicensed 9.8mg, 11mg, 13mg, 14mg, 15mg, 18mg, 20mg & 22mg in 0.9% Sodium Chloride Infusion

BNF BNFc SPC

Pixantrone

RED
Restricted Drug Restricted
FOR ALL PRESCRIBING – Blueteq or High cost drug form required – see link from Formulary homepage.
unlicensedunlicensed Pixantrone 90mg in 0.9% Sodium Chloride Infusion (250mL)

Approved in accordance with NICE TA306.

BNF BNFc SPC
NICE TA306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin's B‑cell lymphoma
Classifications
GREEN
May be initiated in any care setting
Amber SPA
Specialist to advise therapy and provide first 28 days supply, continuation in Primary Care
Amber SPIS
Specialist to initiate and stabilise medicine prior to continuation in Primary Care
SCG
To be prescribed as per Shared Care Guidance. If no SCG in place status reverts to red.
RED
Red medicines are designated as specialist only medicines which should only be prescribed by a specialist, usually within secondary care (either due to the requirement for specialist knowledge, long-term monitoring requirements, or restrictions that mean medicine supplies are only available to hospitals).
DNP
A decision has been made either locally and/or nationally not to routinely commission this preparation. Do not prescribe.
SELF
To be purchased over the counter. May be prescribed for chronic, long term conditions or on admission to hospital if essential.