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Bedfordshire and Luton Joint Formulary
Bedfordshire Hospitals NHS Foundation Trust
Bedfordshire, Luton and Milton Keynes ICB
Formulary Chapter: 2 - Cardiovascular system 
Notes:

Any drug not listed on the Formulary should be considered Non-Formulary - Not recommended for prescribing
Links:
Hypertension Resources For Health Professionals NICE guideline NG136 Hypertension in adults: diagnosis and management
02.06.04 Peripheral vasodilators and related drugs
NICE TA223: Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease

Naftidrofuryl Oxalate 100mg
(Capsules)

GREEN
Restricted Drug Restricted

Naftidrofuryl oxalate may be considered for treating people with intermittent claudication, starting with the least costly preparation, only when:

  • supervised exercise has not led to satisfactory improvement and
  • the person prefers not to be referred for consideration of angioplasty or bypass surgery.

GPs may prescribe naftidrofuryl as a trial treatment option for patients who meet the above two criteria in accordance with NICE TA223 or CG147.

BNF BNFc SPC
NICE CG147: Peripheral arterial disease: diagnosis and management NICE TA223: Cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease

Pentoxifylline 400mg (Trental®)
(MR Tablets)

RED
Restricted Drug Restricted

No longer recommended by NICE for the treatment of intermittent claudication in people with peripheral arterial disease.

Restricted use:
Approved by DTC for the treatment of osteoradionecrosis of the jaw (off-label use). Dose is 400mg BD. Patients are to purchase vitamin E 1000 units daily to take with this treatment.

BNF BNFc SPC
Non formulary items

Cilostazol (Pletal®)

DNP
Non Formulary

Not recommended by NICE TA223 for the treatment of intermittent claudication in people with peripheral arterial disease.

BNF BNFc SPC

Inositol Nicotinate (Hexopal®)

DNP
Non Formulary

Not recommended by NICE TA223 for the treatment of intermittent claudication in people with peripheral arterial disease.

BNF BNFc SPC
02.06.04 Other preparations used in peripheral vascular disease
Classifications
GREEN
May be initiated in any care setting
Amber SPA
Specialist to advise therapy and provide first 28 days supply, continuation in Primary Care
Amber SPIS
Specialist to initiate and stabilise medicine prior to continuation in Primary Care
SCG
To be prescribed as per Shared Care Guidance. If no SCG in place status reverts to red.
RED
Red medicines are designated as specialist only medicines which should only be prescribed by a specialist, usually within secondary care (either due to the requirement for specialist knowledge, long-term monitoring requirements, or restrictions that mean medicine supplies are only available to hospitals).
DNP
A decision has been made either locally and/or nationally not to routinely commission this preparation. Do not prescribe.
SELF
To be purchased over the counter. May be prescribed for chronic, long term conditions or on admission to hospital if essential.