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Bedfordshire and Luton Joint Formulary
Bedfordshire Hospitals NHS Foundation Trust
Bedfordshire, Luton and Milton Keynes ICB
Formulary Chapter: 5 - Infections 
Notes:

For full details on UKHSA guidance for managing common infections with local amendments please see:

BLMK Primary Care Antimicrobial Guidelines hosted via: https://blmkantibioticspubliclive.azurewebsites.net/

Secondary care antimicrobial guidelines:

Bedfordshire Hospitals Foundation Trust: Antimicrobial guidelines are hosted on:  EOLAS Medical App. 
05.03.01 HIV infection
All prescribing for HIV patients should be in line with current BHIVA guidelines

Cabotegravir (Apretude®)
(600 mg prolonged-release suspension for injection; 30 mg film-coated tablets)

RED
Restricted Drug Restricted

Restricted - must be prescribed by HIV consultants only and used in accordance with NICE TA 1106.

NB: 30mg tablets to be used as as an oral lead-in prior to the initiation of cabotegravir injection.

 

Entry added: November 2025

BNF BNFc SPC
NICE TA1106: Cabotegravir for preventing HIV-1 in adults and young people

Cabotegravir (Vocabria®)
(400 mg in 2 mL and 600mg in 3 mL prolonged-release suspension for injection; 30 mg film-coated tablets)

RED
Restricted Drug Restricted

Restricted - must be prescribed by HIV consultants only and used in accordance with NICE TA 757

NB: 30mg tablets to be used as as an oral lead-in prior to the initiation of cabotegravir injection.

BNF BNFc SPC
NICE TA 757 Cabotegravir with rilpivirine for treating HIV-1

Doravirine/ lamivudine/ tenofovir disproxil ( Delstrigo ®)
(Tablets)

RED
Restricted Drug Restricted

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.

Contains 100mg of doravirine, 300mg of lamivudine and 300 mg of tenofovir disoproxil fumarate (equivalent to 245mg of tenofovir disoproxil)

BNF BNFc SPC

Rilpivirine (Rekambys®)
(600 mg in 2 mL and 900 mg in 3 mL prolonged-release suspension for injection)

RED
Restricted Drug Restricted

Restricted - must be prescribed by HIV consultants only in accordance with NICE TA 757

BNF BNFc SPC
NICE TA 757 Cabotegravir with rilpivirine for treating HIV-1

Tenofovir alafenamide, Elvitegravir, Cobicistat & Emtricitabine (Genvoya®)

RED
Restricted Drug Restricted
Contains 150 mg of elvitegravir, 150 mg of cobicistat, 200 mg of emtricitabine and tenofovir alafenamide fumarate equivalent to 10 mg of tenofovir alafenamide.

Restricted - prescribing by HIV Consultants only in accordance with BHIVA guidelines and NHSE Clinical Commissioning policy.
BNF BNFc SPC

Bictegravir, emtricitabine and tenofovir alafenamide (Biktarvy®)

RED
Restricted Drug Restricted

Bictegravir 50mg, emtricitabine 200mg and tenofovir alafenamide 25mg

 

Restricted - must be prescribed by HIV consultants only

To be used in line with NHS England Commissioning Statement

BNF BNFc SPC
Clinical Commissioning Policy: Bictegraviremtricitabine-tenofovir alafenamide for the treatment of HIV-1 in adults

Cobicistat tablets (Tybost®)

RED
Restricted Drug Restricted

Restricted - must be prescribed by HIV consultants only

Pharmacokinetic enhancer used to increase the effect of atazanavir or darunavir.

 

Entry reviewed: April 2022

BNF BNFc SPC
NHSE Clinical Commissioning Policy: Use of cobicistat as a booster in treatment of HIV infection (all ages)

Darunavir, cobicistat, emtricitabine, tenofovir alafenamide (Symtuza®)

RED
Restricted Drug Restricted

Restricted - must be prescribed by HIV Consultants only

BNF BNFc SPC
05.03.01 Nucleoside reverse transcriptase inhibitors
05.03.01 Protease inhibitors
05.03.01 Non-nucleoside reverse transcriptase inhibitors
05.03.01 Other antiretrovirals
05.03.01 Pharmacokinetic enhancers of antiretrovirals
Classifications
GREEN
May be initiated in any care setting
Amber SPA
Specialist to advise therapy and provide first 28 days supply, continuation in Primary Care
Amber SPIS
Specialist to initiate and stabilise medicine prior to continuation in Primary Care
SCG
To be prescribed as per Shared Care Guidance. If no SCG in place status reverts to red.
RED
Red medicines are designated as specialist only medicines which should only be prescribed by a specialist, usually within secondary care (either due to the requirement for specialist knowledge, long-term monitoring requirements, or restrictions that mean medicine supplies are only available to hospitals).
DNP
A decision has been made either locally and/or nationally not to routinely commission this preparation. Do not prescribe.
SELF
To be purchased over the counter. May be prescribed for chronic, long term conditions or on admission to hospital if essential.